منابع مشابه
Effect of etomidate on intracranial pressure and cerebral perfusion pressure.
Ten patients with intracranial lesions, anaesthetized with thiopentone and nitrous oxide (70%) in oxygen (30%) received etomidate 0.2 mg kg-1 i.v. Ventilation was controlled in each patient. Intracranial pressure (i.c.p.) and mean arterial pressure (m.a.p.) were recorded. I.c.p. decreased significantly in all patients (0.01 greater than P greater than 0.001). Although PaCO2 decreased during the...
متن کاملEffect of cerebral perfusion pressure on cerebral cortical microvascular shunting at high intracranial pressure in rats.
BACKGROUND AND PURPOSE Recently, we showed that decreasing cerebral perfusion pressure (CPP) from 70 mm Hg to 50 mm Hg and 30 mm Hg by increasing intracranial pressure (ICP) with a fluid reservoir induces a transition from capillary (CAP) to microvascular shunt (MVS) flow in the uninjured rat brain. This transition was associated with tissue hypoxia, increased blood-brain barrier (BBB) permeabi...
متن کاملDriving cerebral perfusion pressure with pressors: how, which, when?
In traumatic brain injury, cerebral hypoperfusion is associated with adverse outcome, particularly in the early phases of management. This has resulted in the increased use of drugs such as adrenaline, noradrenaline, dopamine and phenylephrine to augment or maintain systemic blood pressures at near normal levels. This is now part of standard practice and is endorsed by the Brain Trauma Foundati...
متن کامل19 Management of Intracranial Pressure and Cerebral Perfusion
The treatment of traumatic brain injury is based on the conceptual distinction between primary and secondary injury. Primary injury comprises the immediate effects of impact. Secondary injury is due to factors other than the direct impact and may begin almost immediately or some time later. The distinction is of course, not so sharp. It is increasingly clear that the impact initiates a series o...
متن کاملCerebral Perfusion Pressure Based Management of Traumatic Brain Injury
Cerebral perfusion pressure (CPP) is the difference between mean arterial pressure (MAP) and intracranial pressure (ICP). Traditionally, management of traumatic brain injury (TBI) depended mainly on ICP control strategies. Based on the evidence that cerebral ischemia plays a major role in causing poor neurological outcome in traumatic brain injury (TBI) and cerebral blood flow autoregulation is...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2015
ISSN: 0007-0912
DOI: 10.1093/bja/aev230